![]() ![]() These include SLC2A9, ABCG2, SLC22A12, GCKR, and PDZK1. Genome-wide association studies (GWAS) have found several genes that are associated with gout. Offending medications include diuretics, low dose aspirin, ethambutol, pyrazinamide, and cyclosporine. Other factors implicated for gout and/or hyperuricemia include older age, male sex, obesity, a purine diet, alcohol, medications, comorbid diseases, and genetics. In fact, only a minority of these patients go on to develop gout. Hyperuricemia is not the only risk factor for gout. ![]() In a study of more than 2000 older adults with gout, those with levels more than 9 mg/dl were three times more likely to have a flare over the next 12 months than those with levels less than 6 mg/dl. People with higher serum urate levels are not only at an elevated risk for gout flare-ups but will also have more frequent flare-ups over time. Hyperuricemia is the leading cause of gout.
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